• Captopril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
• In addition, Captopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.

Therapeutic Indications Of Acetab 25 Mg Tablets

• Treat high blood pressure (hypertension): High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• Treat chronic heart failure (when the heart is not strong enough to work correctly)
• Treat a heart attack:

1. In the short-term (4 weeks), to treat clinically stable patients. In this case, treatment will be started within the first 24 hours of the attack
2. In the long-term, to prevent symptomatic heart failure

• Treat kidney disease in patients with diabetes with High blood pressure

Method Of Administration Of Acetab 25 Mg Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• You can take the tablets before, during, or after meals
• High blood pressure (hypertension):

1. The recommended starting dose is 25-50 mg daily divided into two doses. The dose may be gradually increased until your target blood pressure is reached.
2. The maximum dose is 100-150 mg per day.

• Heart failure:

1. Your doctor will start your treatment under close medical supervision. The usual starting dose is 6.25 mg or 12.5 mg either two or three times a day. The dose may be gradually increased, depending on your response to the treatment.
2. The maintenance dose is 75 to 150 mg per day, divided into two or three doses. The maximum dose is 150 mg per day

• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Acetab 25 Mg Tablets

• Common (may affect up to 1 in 10 people):

1. Sleep disorders
2. Alterations of taste
3. Dizziness
4. Dry, irritant cough without phlegm and/or shortness of breath (dyspnea)
5. Feeling sick and/or vomiting
6. Irritation of the stomach, abdominal pain, diarrhea, constipation, dry mouth
7. Itchy skin with or without a rash, rash, hair loss

• Uncommon (may affect up to 1 in 100 people):

1. Fast heartbeat (tachycardia) and/or fast, irregular heartbeat (tachyarrhythmia)
2. Chest pain and/or chest pain due to a lack of blood and hence oxygen supply of the heart muscle (angina pectoris)
3. Feeling the heart beating in the chest (palpitations)
4. Low blood pressure (hypotension)
5. Pain in fingers or toes while they turn first whitish, then bluish, and finally reddish (Raynaud’s syndrome)
6. Flushes and/or paleness of the skin
7. Swelling of the skin particularly of the face and around the mouth (angioedema).
8. Tiredness and/or feeling unwell
9. Rare (may affect up to 1 in 1,000 people):
10. Loss of appetite
11. Drowsiness and/or headache
12. Tingling, pricking, or numbness of the skin (paresthesia)
13. Soreness of the mouth (stomatitis) and/or sores (ulcers) in the mouth
14. Changes in kidney function include kidney failure, passing more water than normal (polyuria), passing less water than normal (oliguria), passing water more often than normal
15. Allergic reaction in the gut causing severe abdominal pain (intestinal angio-edema)

• Very rare (may affect up to 1 in 10,000 people): Changes in blood count

Pregnancy & Breastfeeding Precautions While Taking Acetab 25 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.