The combination Glibenclamide / Metformin HCl is used to lower blood sugar levels in patients with diabetes mellitus type 2 (non-insulin dependent) along with a proper diet and exercising.

Do not take Glibenclamide / Metformin HCl:

• If you’re allergic to Metformin, Glibenclamide, other sulfonylureas, sulfonamides or any other component of this medicine.
• If you have diabetes mellitus type 1 (insulin dependent)
• If you have liver problems.
• If you have severe kidney problems.
• If you have lactic acidosis or diabetic ketoacidosis (very high blood sugar levels and you experience nausea, vomiting, frequent urination, fatigue and muscle weakness).
• If you are dehydrated (lost  too  much  water  from  your  body  due to  long-lasting  or  severe  diarrhea,  or  if  you  have  vomited  several times  in  a  row).
• If you have a severe infection, such as an infection affecting your lung or your kidney.
• If you are treated for acute heart failure or have recently had a heart attack, have severe problems with your circulation or have breathing difficulties.
• If you are taking a medicine called Bosentan for high blood pressure.
• If you drink a lot of alcohol.