• Paracetamol acts on the hypothalamus to produce an antipyretic effect, as fever develops when the hypothalamus is set to a higher-than-normal temperature.
• Paracetamol may work peripherally to block pain impulse generation; may also inhibit prostaglandin synthesis in CNS
• H1 histamine receptor antagonist; competes for H1-receptor sites in target cells in the respiratory tract, blood vessels, and gastrointestinal tract.
• Chlorpheniramine is a sedative first-generation antihistamine
• Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect.
• Pseudoephedrine is a decongestant used for reducing nasal congestion caused by allergies or the common cold.
• Pseudoephedrine causes blood vessels in the nasal passages to shrink (vasoconstrictor).
• Vasoconstriction reduces nasal congestion by preventing fluid from draining from blood vessels into nasal passages.
• Caffeine acts as a central nervous system (CNS) stimulant, people usually take it to feel more alert and energetic.
• Caffeine can improve mood and help people feel more productive. It is believed to work by blocking the neurotransmitter adenosine's receptors, increasing excitability in the brain.

Therapeutic Indications Of Fludrex Tablets

• It is used for the relief of the following indications:

1. Headache
2. Congestion and sinus pain
3. Sneezing
4. Body aches
5. Itchy and watery eyes
6. Blocked and runny nose
7. Fever
8. Relief from cold and flu symptoms.