• Like all sulfonylureas, Glibenclamide acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors
• Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
• Metformin decreases the intestinal absorption of glucose
• Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

Therapeutic Indications Of Glucovance 2.5/500 Tablets

• It is used to lower blood sugar levels in patients with diabetes mellitus type 2 (non-insulin-dependent). It is used when diet and exercising have failed to control your diabetes

Method Of Administration Of Glucovance 2.5/500 Tablets

• This medicine is intended for adults only.
• Take as indicated by your doctor.
• Take with meals.
• It is important to follow the diet and exercise plan set by your doctor.
• The usual starting dose is Glibenclamide 1.25 – 2.5 mg / Metformin 500 – 1000 mg. It is given once or twice daily.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.