• Sitagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1). Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed.
• Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
• Metformin decreases the intestinal absorption of glucose
• Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

Therapeutic Indications Of Gliptamet 50/1000 Tablets

• This medicine is used to treat a type of diabetes called “type 2 diabetes”
• Sitagliptin and metformin work together to control your blood sugar.
• They increase the levels of insulin after a meal. They also lower the amount of sugar made by your body.
• Along with diet and exercise, this helps lower your blood sugar.
• This medicine can be used alone or together with other antidiabetic medicines, including insulin.

Method Of Administration Of Gliptamet 50/1000 Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• Take one tablet twice daily by mouth with meals to lower your chance of an upset stomach.
• Your doctor may need to increase your dose to control your blood sugar.
• If you have reduced kidney function, your doctor may prescribe a lower dose.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.