Mechanism Of Action Of Paracetamol, Diphenhydramine & Pseudoephedrine

• Paracetamol acts on the hypothalamus to produce an antipyretic effect, as fever develops when the hypothalamus is set to a higher-than-normal temperature.
• Paracetamol may work peripherally to block pain impulse generation; may also inhibit prostaglandin synthesis in CNS
• H1 histamine receptor antagonist; competes for H1-receptor sites in target cells in the respiratory tract, blood vessels, and gastrointestinal tract.
• Chlorpheniramine is a sedative first-generation antihistamine
• Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect.
• Pseudoephedrine is a decongestant used for reducing nasal congestion caused by allergies or the common cold.
• Pseudoephedrine causes blood vessels in the nasal passages to shrink (vasoconstrictor).
• Vasoconstriction reduces nasal congestion by preventing fluid from draining from blood vessels into nasal passages.

Therapeutic Indications Of Flutab Tablets

• It is used for the relief of the following indications:

1. Headache
2. Congestion and sinus pain
3. Sneezing
4. Body aches
5. Itchy and watery eyes
6. Blocked and runny nose
7. Fever
8. Relief from cold and flu symptoms.