• Oral Anti-Diabetic Drugs

Mechanism Of Action Of Vildagliptin & Metformin

• Vildagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1). Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed.
• Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
• Metformin decreases the intestinal absorption of glucose
• Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

Therapeutic Indications Of Galvus Met 50/850 Tablets

• It is indicated as an adjunct to diet and exercise to improve glycemic control in patients whose diabetes is not adequately controlled on metformin hydrochloride or vildagliptin alone

Method Of Administration Of Galvus Met 50/850 Tablets

• It should be given with meals to reduce the gastrointestinal side effects associated with metformin hydrochloride.
• It may be initiated at 50mg/500 mg once daily and gradually titrated to a maximum dose of 50mg/1000 mg twice daily after assessing the adequacy of therapeutic response
• Doses higher than 100mg of vildagliptin are not recommended
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.